Langerhans cell histiocytosis


Histiocytosis X is most often seen in children ages 1 to 15  with the peak incidence at 1-4
years of age.

The rate peaks among children ages 5 to10 years. It most commonly affects skull among the flat bones and femur among the long bones. The diagnostic tests that can be carried out in children are: 

  • Skin biopsy for the presence of Langerhans cells
  • Bone marrow biopsy for the presence of Langerhans cells
  • Complete blood count
  • X-rays skeletal survey to find out number of affected bones.