Glioblastoma NOS - large cystic component

Discussion:

The patient went on to have a resection.

Histology

Microscopic picture: Infiltrative richly cellular new growth composed of pleomorphic astrocytes having hyperchromatic nuclei with brisk mitotic activity. Areas of tumor necrosis observed. Glomeruloid vascular proliferation is noted. 

Diagnosis: Glioblastoma (WHO Grade IV).

Note: As IDH status, in this case, is unavailable, according to the current (2016) revision WHO classification of CNS tumors this tumor is classified as a glioblastoma NOS.

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