What is incorrect about the nigrosome-1? a) Nigrosome-1 is the area with the highest concentration of dopaminergic neurons within the dorso-lateral mesencephalic substantia nigra. b) In normal patients, the classic swallow-tail sign represents the normal nigrosome-1 within the substantia nigra. c) The loss of swallow-tail sign seems not only to present good diagnostic properties, but also seems to determine clinical manifestations characteristics of PD. d) Depletion of nigrosome-1 dopaminergic neurons in Parkinson's disease occur only bilateraly.
Correct answer: "d" Depletion of nigrosome-1 dopaminergic neurons in PD may occur bilaterally or involve only one side. Some studies have shown that asymmetric depletion of nigrosome-1 neurons is also associated with more severe clinical manifestations on the contralateral side.
Illustrated diagrams of cross-sectional midbrain.