Considering the site and appearance of the lesion in radiography, can you mention the lesions that may fit in the differential diagnosis?
The differential diagnosis of a well defined intra-medullary lucent bone lesion with marginal sclerosis and no expansion, may include: Geode, healing benign or malignant bone lesion (e.g. metastasis, eosinophilic granuloma or brown tumour), Brodie’s abscess, benign bone neoplasms (simple bone cyst, enchondroma, chondroblastoma), fibrous dysplasia and osteoblastoma 3
There is an oval shaped well defined intra-medullary lytic lesion involving meta-diaphyseal region of lower tibia. It is seen surrounded by an irregular sclerosis. No cortical breaching and no periosteal reaction.