Sarcoidosis - perilymphatic nodular pattern

Discussion:

Sarcoidosis is a multisystem autoimmune disease characterized by non-caseating granulomas. Lung and lymphatic involvement is seen in 90% of patients. Majority of patient has stable disease or in remission with a minority of patient progressed to lung fibrosis. 

Chest radiograph appearance can be classified according to the Stiltzbach system 1:

  • stage 0: normal
  • stage 1: lymphadenopathy
  • stage 2: lung involvement
  • stage 3: both lung involvement and lymphadenopathy
  • stage 4: lung involvement only
  • stage 5: lung fibrosis.

Although widely known, this classification may not be a good indicator of disease severity. 

CT findings is variable but most commonly manifested by well-defined nodules in the perilymphatic distribution. CT can also better characterized mediastinal adenopathy. Patient with progressive disease can develop pulmonary fibrosis as late sequelae. 

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