Sarcoidosis - perilymphatic nodular pattern
Sarcoidosis is a multisystem autoimmune disease characterized by non-caseating granulomas. Lung and lymphatic involvement is seen in 90% of patients. Majority of patient has stable disease or in remission with a minority of patient progressed to lung fibrosis.
Chest radiograph appearance can be classified according to the Stiltzbach system 1:
- stage 0: normal
- stage 1: lymphadenopathy
- stage 2: lung involvement
- stage 3: both lung involvement and lymphadenopathy
- stage 4: lung involvement only
- stage 5: lung fibrosis.
Although widely known, this classification may not be a good indicator of disease severity.
CT findings is variable but most commonly manifested by well-defined nodules in the perilymphatic distribution. CT can also better characterized mediastinal adenopathy. Patient with progressive disease can develop pulmonary fibrosis as late sequelae.
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