Anaplastic astrocytoma (WHO grade III) of the septum pellucidum

Discussion:

Highly unusual intraventricular mass arising from the septum pellucidum. In a younger patient central neurocytoma would be considered, however, it seems too aggressive for this condition with infiltration into the corpus callosum and the patient is old (ie 70 years).

Histology: High grade glioma being GFAP +ve, p53 strongly positive in many enlarged atypical nuclei, Ki-67 proliferation index is ~25% with positive 1p/19q gene deletion.

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