A 35 year old patient underwent a wide quadrantectomy and axillary level II node dissection for two ductal carcinoma of the upper outer quadrant of the right breast. Both tumors, of 10 and 18 mm respectively, were high grade, estrogen, progesterone receptors and HER2/neu positive; the resection margins were clean; 8 out of 13 axillary lymph nodes removed were metastatic, with extension of tumor beyond the capsule in two. The postoperative period was uneventful, the suction drain was removed after 6 days and no wound infection occurred. Four months after surgery, during chemotherapy with AC regimen (cyclophosphamide, doxorubicin), an edema of the lower quadrants of the operated breast appeared, without lymphedema of the arm. The patient had not yet started radiotherapy.