MICROSCOPIC DESCRIPTION: All the sections show a moderately cellular pituitary adenoma comprising sheets and nests, surrounded by vascularised stroma. The tumour cells have enlarged pleomorphic nuclei, prominent nucleoli and small amounts of eosinophilic cytoplasm. No normal anterior pituitary gland tissue is present. The tumour cells show patchy positivity with TSH and prolactin. The Ki-67 index is about 1%. Immunostains for GH, ACTH, LH and FSH are negative. The features are most consistent with silent subtype 3 adenoma. The slides have been reviewed by A/Prof. Gonzales.
DIAGNOSIS: Pituitary: Features most consistent with silent subtype 3 adenoma.