Sickle cell disease


Frontal and lateral chest radiographs demonstrates multiple bone and soft tissue findings associated with sickle cell disease:

  • H-shaped vertebrae with central end plate depression involving the superior and inferior endplates
  • Bilateral patchy humeral head sclerosis consistent with epiphyseal infarction
  • Absent splenic shadow with loops of bowel replacing the left upper quadrant abdomen suggesting autosplenectomy.  Later confirmed on CT (not shown)
  • Calcified gallstones seen in the right upper quadrant abdomen from radio-opaque bilirubin/pigmented gallstones
  • Enlarged heart secondary to chronic anemia
  • Enlarged liver shadow (not completely imaged) in keeping with hepatomegaly