Primary liver lymphoma (hepatic involvement) is rare and accounts for less than 1% of extranodal lymphoma. The risk factors are viral infections, particularly hepatitis B and C, and Epstein-Barr virus. Women being affected twice as often as men. Symptoms are usually nonspecific with upper left abdominal and epigastric pain, fatigue, weight loss, fever and nausea. Clinically, there are often hepatomegaly and elevated liver function tests.

If lymphoma is suspected (on imaging), the best choice is usually biopsy to confirm the diagnosis, which was also confirmed the diagnosis in this patient.