Canavan disease

Discussion:

This case demonstrates the typical clinical and imaging profile of Canavan's disease.

Note extensive T2 white matter hyperintensity involving the subarcuate U fibers, posterior fossa, internal capsule and cerebellar white matter.

MRS reveals a grossly raised NAA peak, this has been described only in cases of Canavan's disease and is fairly specific.

Differential possibilities include: 

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