This patient was clinically diagnosed with Alzheimer's disease (AD). Both MRI scans were performed within an interval of 5 months, the patient has been showing progressive cognitive impairment. 

Despite the difficulties to demonstrate AD on imaging, this case illustrates a progressive global cerebral atrophy observed in a short interval of time. When applying the medial lobe atrophy score for assessing the images, is possible to say that the patient moves from MTA 1 to MTA 2 in this period.