Neonatal hypoxic-ischemic encephalopathy


The findings described above of white matter injury with sparing of the cortex, deep grey matter and cerebellar hemispheres point to moderate degree neonatal hypoxic ischemic encephalopathy in a preterm newborn child. The striking diffusion restriction of the corpus callosum has a bad prognostic value. The key to understand the different patterns of neonatal hypoxia is understanding the stages of brain maturation and correlating them with the gestational age of the neonate. The developing areas of the brain are more active metabolically and hence more liable to ischemia.