Pathology
Fig 1
Fig 1A: normal hippocampus from another patient for comparison.
MICROSCOPIC DESCRIPTION:
Fig 1B: Serial sections of hippocampus show almost complete loss of neurons from the CA1 sector of the hippocampal cortex as well as from CA3 and CA4. There is relative preservation of neuronal numbers in CA2. There is also depletion of neurons from the dentate fasciculus with dispersion of residual neurons. The neuronal depletion is accompanied by moderate astrocytic gliosis. The features are of hippocampal sclerosis - Blumke Type 1a.
(not shown) The sections of temporal neocortex show preservation of laminar architecture. No features of malformation of cortical development are seen. Scattered neurons are noted in white matter. Myelination appears normal and there is no evidence of tumour.
(not shown) The sections of amygdala show no specific diagnostic abnormality. No features of amygdala dysplasia or sclerosis are seen. There is no evidence of tumour.
DIAGNOSIS:
Hippocampal sclerosis Blumke Type 1b.