Splenic thorotrastosis

Discussion:

In this patient with previous known administration of Thorotrast contrast, findings are in-keeping with splenic accumulation (or thorotrastosis).

Thorotrast is a suspension of radioactive thorium dioxide that was used as a contrast agent until the 1950s. Following administration, it typically accumulates within the body - particularly the liver, spleen, and peripancreatic lymph nodes. Radiographically, it is seen as metallic densities which may have a multinodular, miliary or diffuse pattern of distribution. Due to Thorotrast being an alpha emitter with a very long half-life, it is highly carcinogenic, and thus is no longer in use.

 

Case uploaded on behalf of and courtesy of Dr Paul McCoubrie.

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