Malignant breast calcification


MICROSCOPIC DESCRIPTION: Multiple core biopsies show a grade 2 invasive carcinoma comprising of nests, single files, trabeculae and tubules of epithelioid cells with moderately pleomorphic nuclei. There is a moderate number of mitoses (12/10hpf). Lymphovascular invasion is present. Tumor cells are ER+ (strong, 100%), PR+ (strong 100%), HER2- (1+), Ki67 30%, E-cadherin+.

DIAGNOSIS: R breast core biopsy, 1 o'clock 4cm from nipple: Invasive ductal carcinoma, grade 2, ER+, PR+, HER2-, Ki67 30%.