Primary bone lymphoma (PBL) is a less common manifestation of lymphoma than secondary involvement from disseminated lymphoma.

Diffuse large B cell lymphoma (DLBCL) is the most common subtype. The bony pelvis and femur are the most common locations.

Differential diagnosis

For plain film presentation of permeative bone destruction consider ¹:

• infection
• eosinophilic granuloma
• Ewing sarcoma
• skeletal metastases