Acute pancreatitis occurs in approximately 5% of diagnostic procedures and 10% of therapeutic procedures. A commonly used definition of post-ERCP pancreatitis is abdominal pain for >24 hours after the procedure and levels of serum pancreatic enzymes three times above normal. This definition excludes the 30–75% of patients who are asymptomatic and have an elevated amylase level alone. Asymptomatic hyperamylasemia peaks 90 minutes to 4 hours after ERCP and resolves within 48 hours.