Primary CNS lymphoma (PCNSL)


This case illustrates imaging features of a callosal periventricular lesion in an elderly patient, which differential is made basically in between GBM and lymphoma (primary central nervous system lymphoma). Note that the area with microhemorrhage and the rim appearances and not that striking, although clearly present, low ADC areas can make it difficult to distinguish both possible etiologies, but the pattern of enhancement, which is vivid and has some fuzzy margins, is quite suggestive for lymphoma; further confirmed on biopsy.