Perineural spread of squamous cell carcinoma: infra-orbital nerve


Perineural spread of SCC in the head and neck is difficult to detect on MRI and requires meticulous technique (including high resolution pre and post contrast), high index of suspicion and careful examination of the cranial nerves adjacent to the site of primary neoplasm. The significance of detection is that prognosis following excision of SCC diminishes substantially and aggressive treatment including radiotherapy is required.  In this case there was excellent response to radiation therapy.