Virchow-Robin spaces or perivascular spaces are small pial lined, cystic structures in the brain and are filled with interstitial fluid. They are normal spaces, identified in all age groups and are common in places where the penetrating vessels enter into the substance of the brain. Occasionally, these spaces can be enlarged and are termed as giant tumefactive perivascular spaces.¹

It is important to recognize these to avoid unnecessary biopsy and potentially devastating complications.