Non-ossifying fibroma (NOF)


Fibroxanthomas can be divided into:

  1. non-ossifying fibroma (>2 cm)

  2. fibrous cortical defect (<2 cm)

Both are pathologically identical.

Non-ossifying fibromas have the following features (all shown here):

  1. present in adolescents and young adults

  2. commonest location is the femur and tibia

  3. dia-metaphyseal in location

  4. eccentric with mild expansion

  5. well defined lucent lesion with a sclerotic margin

  6. cortical thinning, but not breach

Lesions are asymptomatic and are usually an incidental finding. Lesions often spontaneously regress.

Case courtesy of Dr. Ian Bickle.

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