The patient was diagnosed with lupus cerebritis and lupus CNS vasculitis. She had a history of lupus and lupus nephritis, resulting in end-stage renal disease and the need for hemodialysis. She presented with new-onset generalized seizures. High-dose steroids were given for the cerebral edema. Lumbar puncture performed after edema subsided was significant for a lymphocytosis and oligoclonal bands, nonspecific findings which can be seen with lupus cerebritis 1. CSF and blood bacterial, viral, and fungal studies were negative.