Cingulate island sign

Discussion:

Dementia with Lewy bodies (DLB) is one of the most common types of degenerative dementia, secondary to Alzheimer disease (AD). Clinically, DLB is characterized by progressive dementia, parkinsonism, fluctuating cognition, recurrent complex visual eye hallucinations and rapid eye movement sleep behavior disorder.

Several biomarkers are used clinically in the differential diagnosis of DLB. The cingulate island sign is a supportive biomarker in discriminating DLB from AD according to the diagnostic criteria and refers to the relative preservation of posterior cingulate cortex metabolism, in relation to the parietal and occipital lobes.

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