Alobar holoprosencephaly - antenatal

Discussion:

Ultrasound findings most consistent with alobar holoprosencephaly

The main differential diagnosis includes:

  • hydranencephaly
    • thalami usually visible and not fused
    • falx cerebri usually present
    • no associated midline facial abnormalities
    • no cortex present, or sometimes small islands of tissue
  • severe hydrocephalus
    • thalami not fused
    • no associated midline facial abnormalities
    • falx cerebri usually present
    • bilateral choroid plexus
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