Infiltrative hepatocellular carcinoma with portal vein tumor thrombosis


This patient is known to the clinics and is in a palliative treatment. This is a poor prognosis case of HCC with portal vein invasion. In contrast to the nodular or massive subtype of HCC, infiltrative HCC isn't well defined. Malignant portal vein thrombosis is often seen with infiltrative HCC, as in this case. 

The patient had a liver biopsy a few months prior to this study: 

Microscopy: The core biopsies, cirrhotic liver and tumor, comprised of large polygonal hepatoid cells with variable nuclei and prominent nucleoli with scattered atypical mitoses, comprising trabecular plates greater than 3 cells in width. The cells show eosinophilic cell cytoplasm. There are frequent necrotic cells.

Conclusion: Core biopsy of liver showing cirrhotic liver containing moderately well-differentiated hepatocellular carcinoma.