Pancraniosynostosis with premature closure of the coronal, sagittal, and lambdoid sutures with a subsequent cloverleaf deformity of the skull. There is also mid-face hypoplasia, which suggests syndromic etiology.

Cloverleaf skull or Kleeblattschadel skull represents a severe form of pansynostosis. It's an extremely rare disease.

It occurs intrauterine with closure of the sagittal, coronal and lambdoid sutures.

It's usually associated with:

• thanatophoric dysplasia
• severe Apert syndrome
• severe Crouzon syndrome
• Carpenter syndrome
• Pfeiffer syndrome