Cervical spinal neurofibroma in a patient with NF1

Discussion:

This patient has a previous history of NF1 as suggested by the presence of dural ectasia. The most likely diagnosis for such a lesion is a neurofibroma considering the previous history and radiological findings. However, hemorrhagic changes are atypical. Internal calcifications are ever rarer.

The main differentials would be schwannoma and meningioma.

Pathology report:

  • Dense fibrous tissue, pieces of old altered blood and one piece of tumor tissue.
  • The tumor tissue is moderately cellular and consists of spindle cells with small, bland nuclei and inconspicuous cytoplasm, within a dense fibrous stroma.  The cells are haphazardly arranged.
  • No mitoses are identified and there is no tumor necrosis.
  • The tumor cells stain S100 positive and the features are most consistent with a neurofibroma.
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