Playlist 'Chest' by Abdulrahman Emam

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Questions
Findings

What are the histopathological features of a silicone nodule biopsy?

Silicone nodules are firm and discrete lesions with a dark pigment, which typically occur around bronchioles and small pulmonary arteries. Fibroblasts and other immune cells are characteristically around these nodules.

Question 2

In addition to the direct toxic effects of silicone on lung parenchyma, what other processes are known to contribute to the pathology of silicosis?

Show Answer

Inflammatory cytokines such as interleukin-1 and TNF-alpha, as well as the generation of free radicals, are all known to contribute to lung damage and fibrosis in silicosis.

Question 3

What is the etiology of silicosis?

Show Answer

Inhalation of crystalline silicon dioxide, almost always due to occupational exposure.

Presentation

No past medical history presented with progressively worsening dyspnea on exertion and dry cough for 2 months. Working as a granite cutter for 30 years.

Patient Data

Age:	50 years
Gender:	Male

Radiopaedia.org

Patient Data