Esophageal adenocarcinoma (T3N1)


Esophageal carcinoma staging requires endoscopic ultrasound and biopsy for T1-T3 disease:

  • Tis: esophageal carcinoma in situ (pathologic diagnosis: no invasion into 
  • T1:  invasion into the lamina propria, muscularis mucosa, or submucosa
  • T2:  invasion into muscularis propria
  • T3:  invasion into the adventitia/subserosa

T4 disease can also be diagnosed with endoscopic ultrasound, but clear invasion of adjacent structures can often also be seen on cross-sectional imaging

  • T4: invasion into structures adjacent to the esophagus.

Nodal staging is based on the number of enlarged lymph nodes in the paraesophageal, perigastric, and celiac stations:

  • N1: 1-2 nodes
  • N2: 3-6 nodes
  • N3: >7 nodes

The TNM of esophageal squamous cell carcinoma and esophageal adenocarcinoma are staged differently.