Ewing sarcoma - C1


A vertebral mass in an otherwise well child which has no matrix mineralization / ossification has a relatively limited differential including:

  • benign
    • eosinophilic granuloma
    • aneurysmal bone cyst: fluid fluid levels would be typical
    • giant cell tumor
  • malignant
    • Ewing sarcoma
    • lymphoma 

Given the clearly aggressive interface with bone, which is destroyed, a malignancy was unfortunately the most likely diagnosis in this case, and Ewing's sarcoma the most likely entity.