This is case of extensive acute widepsread thrombo-embolic disease with the patient presenting with ischemia to the small and large bowel, spleen, liver, kidneys, ovaries, and lower limbs. She was previously healthy with nil pro-thrombotic risk factors. She underwent urgent laparotomy and embolectomy with subsequent small and large bowel resections, bilateral oophorectomy, and foot amputation. The cause for this remains uncertain.