Large bowel obstruction


Colonoscopy revealed a lumen occluding circumferential proliferative growth in the descending colon. 

Microscopic Description: Section shows fragments of large intestinal mucosa containing part of an ulcerating neoplasm with villous architecture in places lined by cells displaying nuclear crowding, stratification and hyperchromasia, variably conspicuous nucleoli and frequent mitosis. Disorganized glands with luminal necrosis and moderate to severe degree of cytological atypia and apical mitosis are present in the lamina propria and also between muscularis mucosal fibers. There is associated inflammation and desmoplasia

Colonic biopsy conclusion: Moderately differentiated colon adenocarcinoma.