Creutzfeldt-Jakob disease (CJD)


Cerebrospinal fluid was positive for 14-3-3 protein consistent with a diagnosis of Creutzfeld-Jakob disease (CJD). 

Note the high signal in the caudate heads and putamen on FLAIR. There is also some cortical ribboning seen on DWI. 

From a psychiatric point of view, it is important to be aware that the earliest clinical manifestations of CJD can be mental state changes and patients may initially present with a complaint such as depression.