Search results for “cerebral atrophy”

8 results found
Article

Adrenomyeloneuropathy

Adrenomyeloneuropathy is a form of X-linked adrenoleukodystrophy characterized by pronounced involvement of the spinal cord with only minor involvement of the cerebral white matter.  Clinical presentation Clinical presentation depends on whether or not there is also cerebral involvement.  In ...
Article

Friedreich ataxia

Friedreich ataxia is the most common hereditary progressive ataxia. Epidemiology Thought to have an estimated prevalence of ~1:50,000. There is no recognized gender predilection. Typically present in childhood to adolescence 11. Those with a higher number of trinucleotide repeats (>500) are t...
Article

Subacute combined degeneration of the cord

Subacute combined degeneration of the cord (SACD) is caused by vitamin B12 deficiency. Epidemiology Most common in patients older than 40 and especially older than 60 7.  Clinical presentation The clinical presentation of SACD is usually with loss of vibration and proprioception in the hands...
Article

Nitrous oxide toxicity

Nitrous oxide (N2O) toxicity has serious medical sequelae affecting both the CNS and the bone marrow. Neurological effects include encephalopathy, myelopathy, and neuropathy. This results from demyelination and gliosis due to selective inhibition of vitamin B12 1. Bone marrow toxicity may lead t...
Article

Scoliosis

Scoliosis is defined as an abnormal lateral curvature of the spine. It is quite common in young individuals and is often idiopathic and asymptomatic. In some cases, however, it is the result of underlying structural or neurological abnormalities.  Terminology By definition, scoliosis is any la...
Article

HTLV-1-associated myelopathy

HTLV-1-associated myelopathy (also known as tropical spastic paraparesis) is primarily seen in Japan, Melanesia and the Caribbean and presents with chronic spastic paraparesis.  Terminology This condition has been independently described in Japan (HTLV-1 associated myelopathy) and in the Carib...
Article

Systemic lupus erythematosus (CNS manifestations)

Central nervous system manifestations of systemic lupus erythematosus (CNS lupus) describe a wide variety of neuropsychiatric manifestations that are secondary to systemic lupus erythematosus (SLE) in the central nervous system (CNS). For a general discussion, and for links to other system spec...
Article

Neuromyelitis optica spectrum disorder

Neuromyelis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) are closely related severe demyelinating diseases caused by an autoantibody to the aquaporin-4 water channel. The classic presentation of NMO is with the triad of optic neuritis, longitudinally extensive myelitis, and po...

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