Articles
Articles are a collaborative effort to provide a single canonical page on all topics relevant to the practice of radiology. As such, articles are written and continuously improved upon by countless contributing members. Our dedicated editors oversee each edit for accuracy and style. Find out more about articles.
105 results
Article
TNM staging system
The TNM staging system (officially known as the TNM classification system of malignant tumors) is a cancer staging system overseen and published by the Union for International Cancer Control (UICC). The American Joint Committee on Cancer (AJCC) publishes the AJCC Cancer Staging Manual which is b...
Article
Enneking surgical staging system
The Enneking surgical staging system (also known as the MSTS system) is based on tumor grade, local spread and metastatic disease of malignant musculoskeletal tumors.
It does not classify skull tumors or marrow-originating tumors (e.g. lymphoma, plasmacytoma / multiple myeloma, Ewing sarcoma) 1...
Article
WHO criteria in tumor response
The WHO criteria were developed in the 1980s under the auspices of the World Health Organization (WHO) to standardize reporting of cancers in clinical trials. Nowadays, newer criteria often based on the WHO criteria (such as RECIST, mRECIST, Choi criteria, Lugano response criteria), have widely...
Article
Necrotizing enterocolitis (staging)
Necrotizing enterocolitis (NEC) can be staged into three groups, to guide appropriate treatment based on the work of Bell et al. 1. In general, stage I and II are managed medically whereas stage III is managed surgically.
stage I
clinical signs
lethargy, temperature instability, apnea, bradyc...
Article
Anal cancer (staging)
Anal cancer staging refers to the TNM classification of anal cancer published by the American Joint Committee on Cancer (AJCC). The most recent version of the AJCC staging system for anal cancer, version 9, was published in 2022 with a required use date of 1 January 2023 3.
Primary tumor (T)
T...
Article
Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST)
Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) are guidelines to asses tumors that makes use of positron emission tomography (PET) to provide functional information to help determine tumor viability.
The criteria consist of four categories: complete metabolic response ...
Article
Chandler classification of orbital infections
Chandler classification is the most commonly used system for dividing the different types of orbital cellulitis. The system describes five stages 1,2:
stage I: preseptal orbital cellulitis with inflammation and edema anterior to the orbital septum.
stage II: orbital cellulitis with extension o...
Article
Ovarian cancer (staging)
The most commonly adopted ovarian cancer staging system is the FIGO staging system. The staging system is from 2014 1:
CT is considered the best imaging modality for staging ovarian cancer 4.
stage I: tumor limited to the ovaries
stage Ia:
tumor limited to one ovary
capsule intact
no tu...
Article
Perihilar cholangiocarcinoma (staging)
Perihilar cholangiocarcinoma staging is, for prognostication, most commonly conducted using the TNM staging classification of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC). As of 2018, the staging criteria are in their 8th edition and reflected below...
Article
Mucosal melanoma of the head and neck (staging)
Mucosal melanoma of the head and neck staging refers to TNM staging of mucosal melanoma involving the nasal cavity, paranasal sinuses, oral cavity, and, less commonly, pharynx and larynx. The system is distinct from staging of carcinomas of those sites and of cutaneous melanoma. The following ar...
Article
B symptoms
The B symptoms (a.k.a. inflammatory symptoms) are a triad of systemic symptoms associated with more advanced disease and a poorer outcome in lymphoma 1,2:
weight loss
>10% unintentional decrease in body weight in the 6 months preceding the diagnosis
fever: >38°C
night sweats
B symptoms are ...
Article
Modified Ringertz grading system for diffuse astrocytomas
The modified Ringertz grading system has historically been one of the more frequently used grading systems for diffuse astrocytomas, but has essentially been replaced by the WHO grading system.
Unlike the WHO grading system and St Anne-Mayo grading system (also known as the Dumas-Duport grading...
Article
Head and neck cancer therapy response interpretation (Hopkins criteria)
The head and neck cancer therapy response interpretation (Hopkins criteria) is a qualitative system of interpretation for therapy response assessment using PET-CT.
Background
Widely used options for therapy response assessment are clinical examination, histopathology, CT and MR imaging, howeve...
Article
Unknown primary tumors of the head and neck (staging)
Unknown primary tumors of the head and neck staging refers to TNM staging of metastatic carcinomas in the head and neck region without an identifiable primary tumor. The typical scenario involves squamous cell carcinoma present in a cervical lymph node, no obvious primary source on clinical exam...
Article
Prostate cancer (staging)
Prostate cancer staging takes into account a TNM staging system (primary site, nodal and distant metastases), pretreatment PSA and histological grading. The Gleason score is used to determine the Grade Group.
A superseded staging system is the Whitmore-Jewett staging system.
Additionally, the...
Article
Cholangiocarcinoma (staging)
Cholangiocarcinoma staging is most commonly classified using the TNM staging systems of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC), which starting 1 January 2018 is according to its 8th edition. There are separate systems depending on whether the ...
Article
Catterall classification of Perthes disease
The Catterall classification of Perthes disease is based on radiographic appearances of the epiphysis and metaphysis visible in osteonecrosis of the femoral head:
stage I
bone absorption changes visible in the anterior aspect of the epiphysis of femoral head
changes are visible best in frog l...
Article
Salter-Thompson classification of Perthes disease
The Salter-Thompson classification of Perthes disease simplifies the Catterall classification into two groups. Based on the radiographic crescent sign, we can distinguish:
group A: including Catteral groups I and II, where the crescent sign involves less than 50% of the femoral head
group B: i...
Article
Vaginal cancer (staging)
The staging of primary vaginal cancer covers all histological subtypes and is as follows
FIGO staging system
stage 0: carcinoma in situ
stage I: tumor confined to vagina
stage II: invasion of paravaginal tissues but no extension beyond pelvic side walls
stage III: extension to pelvic side w...
Article
Differentiated thyroid cancer (staging)
Differentiated thyroid cancer staging refers to TNM staging of papillary thyroid cancer and follicular thyroid cancer. Anaplastic thyroid carcinoma and medullary thyroid carcinoma are staged separately. The following article reflects the 8th edition manual published by the American Joint Committ...
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