Items tagged “immunology”

7 results found
Article

Hyper IgE syndrome

Hyperimmunoglobulin E (hyper IgE) syndrome (HIES), also known as Job syndrome, consists of heterogeneous group of complex hereditary combined B- and T-cell immune deficiency diseases characterised by recurrent Staph aureus chest infections, characteristic coarse facial appearance and dental prob...
Article

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement. It is also sometimes classified as a vasculitis.  Epidemiology There is an overall increased female predilection. In adults, women are affected 9-13 times more than males. In children, this ratio i...
Article

Myasthenia gravis

Myasthenia gravis (MG) is the most common neuromuscular junction disease, and presents with increasing fatigue brought on by exertion.  Epidemiology Incidence is estimated at 15-20 per 100,000 1,2. Females are more affected (3:1) under the age of 40, but males are more affected over the age of...
Article

IgG4-related disease

IgG4-related disease (IgG4-RD) is a systemic disease that is characterised by extensive IgG4-positive plasma cells and T-lymphocyte infiltration of various organs. Terminology This condition has been known by many other names in the past, such as IgG4-related sclerosing disease, IgG4-related s...
Article

IgG4-related hypophysitis

IgG4-related hypophysitis is a rare cause of inflammation of the pituitary gland and an uncommon manifestation of the systemic IgG4-related disease (IgG4-RD). Epidemiology Although IgG4-RD tends to present in middle-aged and elderly men, the gender ratio is more balanced in patients with IgG4-...
Article

IgG4-related lung disease

IgG4-related lung disease is a recently described condition. It may occur with or without systemic involvement. It is considered part of the spectrum of IgG-4 related disease. Radiographic features CT On HRCT of the chest, it may be categorised into four major subtypes 5: solid nodular type ...
Article

Systemic lupus erythematosus (CNS manifestations)

Central nervous system manifestations of systemic lupus erythematosus (CNS lupus) describe a wide variety of neuropsychiatric manifestations that are secondary to systemic lupus erythematosus (SLE) in the central nervous system (CNS). For a general discussion, and for links to other system spec...

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