Items tagged “immunology”

8 results found

IgG4-related disease

IgG4-related disease (IgG4-RD) is a systemic disease that is characterized by extensive IgG4-positive plasma cells and T-lymphocyte infiltration of various organs. Terminology This condition has been known by many other names in the past, such as IgG4-related sclerosing disease, IgG4-related s...

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement. Although abnormalities in almost every aspect of the immune system have been found, the key defect is thought to result from a loss of self-tolerance to auto-antigens. Epidemiology There is a stron...

IgG4-related lung disease

IgG4-related lung disease is a recently described condition. It may occur with or without systemic involvement. It is considered part of the spectrum of IgG4-related disease. Radiographic features CT On HRCT of the chest, it may be categorized into four major subtypes 5: solid nodular subtyp...

Hyperimmunoglobulin IgE syndrome

Hyperimmunoglobulin E (hyper IgE) syndrome (HIES), also known as Job syndrome, consists of a heterogeneous group of complex hereditary combined B- and T-cell immune deficiency diseases characterized by recurrent Staphylococcus aureus chest infections, characteristic coarse facial appearance and ...

Myasthenia gravis

Myasthenia gravis (MG) is the most common neuromuscular junction disease and presents with weakness worsened by exertion but improving with rest.  Epidemiology Incidence is estimated at 15-20 per 100,000 1,2. Females are more affected (3:1) under the age of 40, but males are more affected by t...

IgG4-related hypophysitis

IgG4-related hypophysitis is a rare cause of inflammation of the pituitary gland and an uncommon manifestation of the systemic IgG4-related disease (IgG4-RD). Epidemiology Although IgG4-RD tends to present in middle-aged and elderly men, the gender ratio is more balanced in patients with IgG4-...

Systemic lupus erythematosus (CNS manifestations)

Central nervous system manifestations of systemic lupus erythematosus (CNS lupus) describe a wide variety of neuropsychiatric manifestations that are secondary to systemic lupus erythematosus (SLE) in the central nervous system (CNS). For a general discussion, and for links to other system spec...

Lymphoma response to immunomodulatory therapy criteria (LYRIC)

The Lymphoma Response to Immunomodulatory Therapy Criteria (LYRIC) represents an adaptation of the Lugano classification for the evaluation of lymphoma after immune-based treatment. During immunomodulatory agents (e.g. checkpoint inhibitors) therapy, imaging findings suggestive of progressive d...

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