Items tagged “nuclear medicine”

Theranostics, also known as  theragnostics 6, uses a diagnostic examination to determine if a patient may benefit from a specific therapeutic drug and thus couples the therapy with diagnostic information specific for the intended target 2. Theranostics promises improved patient selection for th...

F-18 DOPA (3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine) is a PET radiotracer primarily used in the evaluation of neuropsychiatric diseases, movement disorders, and brain malignancies 1.  Production L-DOPA is the nonproteinogenic amino acid precursor to dopamine with F-18 DOPA, in recent years,...

Renal imaging in nuclear medicine is a method to assess the kidneys and collecting systems via multiple different radioactive tracers. Dynamic renal imaging is performed using Tc-99m MAG3 or Tc-99m DTPA, and static renal imaging is performed with Tc-99m DMSA. In addition, Tc-99m DTPA can be use...

Tc99m-Mebrofenin: trimethyl bromo IDA, also known as TBIDA, or under the trade name Choletec, is a diagnostic radiopharmaceutical used in hepatobiliary imaging. It is one of the Tc99m IDA (iminodiacetic acid) analogs. It is taken up by hepatocytes through the same membrane transport mechanism as...

The flip-flop fungus sign suggests benign pulmonary disease on FDG-PET 1-4. Lung cancer nodules demonstrate increasing FDG-avidity as the tumor grows. Lymph node spread occurs later and is therefore at an earlier stage of development and usually exhibits lower FDG-avidity 4. Acutely, FDG-avidi...

Iodine-131 iobenguane, trade name Azedra, sometimes referred to as I-131 MIBG, is a theranostic (i.e. both therapeutic and diagnostic) agent used for the treatment of unresectable pheochromocytomas, paragangliomas, carcinoid, and neuroblastomas.   It is created using the high specificity Ultratr...

Lutetium-177 dotatate, also known as Lu-177 oxodotreotide and by the trade name Lutathera (Novartis Pharmaceuticals Corporation, USA), is a theranostic agent approved as a second-line agent for the treatment of patients with inoperable and/or metastatic well-differentiated neuroendocrine tumors ...

Lutetium-177 vipivotide tetraxetan, trade name Pluvicto, also known as 177Lu-PSMA-617, is a theranostic (i.e. both therapeutic and diagnostic) agent approved as a treatment for adult patients with treatment-resistant advanced metastatic prostate cancer.  The treatment works by binding to cancer ...

Radium-223 dichloride, trade name Xofigo, is a radiopharmaceutical approved for the treatment of patients with symptomatic bone metastases and no visceral disease from prostate cancer resistant to anti androgen therapy. The molecule mimics calcium and forms a complex with hydroxyapatite at sites...