Items tagged “pancreas”

52 results found
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Pancreatoblastoma

Pancreatoblastomas are rare paediatric tumours of the pancreas. However, they are the most common pancreatic neoplasm of childhood and are often associated with a raised alpha-fetoprotein. Epidemiology There is slight male predilection. Usually occurs in the first decade of life with a mean ag...
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Pancreatic neoplasms

There are numerous primary pancreatic neoplasms, in part due to the mixed endocrine and exocrine components. Classification Classification based on function exocrine: ~99% of all primary pancreatic neoplasms pancreatic ductal adenocarcinoma ~90-95% cystic neoplasm intraductal papillary muc...
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Pancreatic pseudocyst

Pancreatic pseudocysts are common sequelae of acute pancreatitis or chronic pancreatitis, and the most common cystic lesion of the pancreas. They are important both in terms of management and differentiation from other cystic processes or masses in this region. Terminology The following are th...
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Autoimmune pancreatitis (diagnostic criteria)

There are several sets of diagnostic criteria for autoimmune pancreatitis (AIP), with some overlap and contradictions. At the time of writing (July 2016), these are the most widely used sets of diagnostic criteria. Asian 2008 AIP diagnostic criteria both criteria I to be fulfilled one criter...
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Pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma makes up the vast majority (~90%) of all pancreatic neoplasms and remains a disease with a very poor prognosis and high morbidity. On imaging, it usually presents as a hypodense mass on CT that is poorly marginated, which may encase vessels and the common biliar...
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Pancreatic metastases

Pancreatic metastases are uncommon and are only found in a minority (3-12%) of patients with widespread metastatic disease at autopsy . They account for only 2-5% of all pancreatic malignancies. Although essentially any primary may eventually deposit in the panaceas the most common primaries en...
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Autoimmune pancreatitis

Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis associated with autoimmune manifestations on clinical, histological, and laboratory grounds 1. Distinguishing this entity from other forms of chronic pancreatitis (such as alcohol-induced) is important as steroid treatment is effec...
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Acute pancreatitis

Acute pancreatitis is an acute inflammation of the pancreas and is a potentially life-threatening condition. The diagnosis of acute pancreatitis is made by fulfilling two of the following three criteria 8: acute onset of persistent, severe epigastric pain (i.e. pain consistent with acute pancr...
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Intraductal papillary mucinous neoplasm

Intraductal papillary mucinous neoplasms or tumours (IPMNs or IMPTs) are cystic tumours of the pancreas. Epidemiology These tumours are most frequently identified in older patients (50-60 years of age) 6. Main duct type (see below) appears to present a decade or so earlier on average than bran...
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Paraduodenal pancreatitis

Paraduodenal pancreatitis is an uncommon type of focal chronic pancreatitis affecting the groove between the head of the pancreas, the duodenum and the common bile duct. Terminology The following entities with which it shares clinicopathological features are unified by this term and should no ...
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Chronic pancreatitis

Chronic pancreatitis represents the end result of a continuous, prolonged, inflammatory and fibrosing process that affects the pancreas. This results in irreversible morphologic changes and permanent endocrine and exocrine pancreatic dysfunction. Epidemiology The most common cause of chronic p...
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Endocrine tumours of the pancreas

Endocrine tumours of the pancreas arise from the pancreatic islet cells and include some distinct tumours that match the cell type of origin.  Terminology Pancreatic endocrine tumours have commonly been referred to as "islet cell tumours", referring to the islets of Langerhans, from which they...
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Insulinoma

Insulinomas are the most common sporadic endocrine tumour of the pancreas. Epidemiology Account for 40% of syndromic pancreatic endocrine tumours. Overall incidence of ~0.0003%. Clinical presentation Typically insulinomas present with Whipple's triad consisting of: fasting hypoglycemia (<50...
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Whipple triad

Whipple triad is the clinical presentation of pancreatic insulinomas and consists of: fasting hypoglycemia (<50 mg/dl) symptoms of hypoglycemia immediate relief of symptoms after the administration of IV glucose History and etymology As a good piece of trivia, one would suspect that Whipple...
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Gastrinoma

Gastrinomas are the second most common pancreatic endocrine tumour and the most common type in the setting of multiple endocrine neoplasia type I (MEN I). Epidemiology Most gastrinomas are sporadic, although some are seen in the setting of multiple endocrine neoplasia type I (MEN I). In genera...
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Glucagonoma

Glucagonomas are pancreatic endocrine tumours that secrete glucagon. Most lesions are malignant. Epidemiology They are rare with an incidence of 0.000005%. Equal incidence in middle-aged men and women.  Clinical presentation Most patients present with a necrolytic migratory rash and various ...
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Causes of pancreatitis (mnemonic)

A catchy and early learnt mnemonic for recalling some of the causes of pancreatitis is: I GET SMASHED Mnemonic I: idiopathic G: gallstones E: ethanol (alcohol) T: trauma S: steroids  M: mumps (and other infections) / malignancy A: autoimmune S: scorpion stings/spider bites H: hyperlip...
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Solid pseudopapillary tumour of the pancreas

Solid pseudopapillary tumours (SPT) of the pancreas are rare (usually benign) pancreatic tumours. Terminology The tumour has been referred to with multiple different names, including: solid pseudopapillary tumour (SPT) of the pancreas solid pseudopapillary neoplasm (SPN) solid pseudopapilla...
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Pancreatic duct diameter

The diameter of the (main) pancreatic duct is a commonly assessed parameter in imaging. Gross anatomy The duct diameter is greatest at the head and neck region and is slightly narrower towards the body and tail. Its normal reported value ranges between 1-3.5 mm 5, 8: head: 3.5 mm body: 2.5 m...
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Pancreatic ducts

The pancreatic ductal embryology is moderately complicated, leading to a number of anatomical variants of the pancreatic ducts, many of which are clinically significant. The normal arrangement is for the entire pancreas to be drained via a single duct, to the ampulla of Vater through the sphinc...

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