Items tagged “radiopharmaceutical”

19 results found
Article

MIBG

MIBG scan is a scintigraphic study that uses metaiodobenzylguanidine, norepinephrine analog, labeled to iodine-123 or iodine-131. It is indicated in the investigation of pheochromocytoma. MIBG is positive in: neuroblastoma olfactory neuroblastoma 1 carcinoid tumor 4 paraganglioma pheochrom...
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Octreotide scintigraphy

Octreotide scintigraphy uses 111In-labeled octreotide which is a somatostatin analog; it is also known as an OctreoscanTM, a brand name for 111In-labeled pentetreotide; pentetreotide is a DTPA-conjugated form of octreotide, originally manufactured by Mallinckrodt Nuclear Medicine LLC, which now ...
Article

Technetium agents

Technetium agents based on the technetium-99m (Tc-99m) radioisotope are frequently used agents in medical imaging. A radiopharmaceutical labeled with Tc-99m constitutes a coordination complex in which ligands bond to a central atom of Tc-99m by coordinate covalent bonds 4 . The radioactive tech...
Article

Radiopharmaceuticals

Radiopharmaceuticals are drugs that are bound to radioactive substances.  The pharmaceutically active portion determines the activity that will be measured and the radioactive portion emits radiation that can be measured by the scanner. A number of radiopharmaceuticals are used in human imaging...
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Tc-99m sulfur colloid

Technetium-99m sulfur colloid is one of the technetium radiopharmaceuticals. Characteristics photon energy: 140 keV physical half-life: 6 hours biological half-life normal distribution: liver: 85% spleen: 10% bone marrow: 5% excretion: hepatic target organ: liver, spleen pharmacokinet...
Article

Xenon-133

Xenon-133 is a radiopharmaceutical principally used when a performing VQ scan. Inhalation of this gas can also be used to assess cerebral blood flow. Mode of decay: Beta decay photon energy: 81 KeV physical half-life: 5.27 days biological half-life: 30 seconds normal distribution: lungs <1...
Article

Iodine-123

Iodine-123 (I123 or I-123) is a radioisotope of the element iodine (atomic number 53) used in nuclear medicine imaging including to scan the thyroid gland.  Uses, dosages, and time of Imaging standard scan: 3.7-14.8 MBq (100-400 μCi) PO, image at 4-6 or 24 hours thyroid cancer scan: 55.5 MBq ...
Article

Tc-99m DMSA

Tc-99m DMSA (2,3 dimercaptosuccinic acid) is a technetium radiopharmaceutical used in renal imaging to evaluate renal structure and morphology, particularly in pediatric imaging for detection of scarring and pyelonephritis. DMSA is an ideal agent for assessment of the renal cortex as it binds to...
Article

Tc-99m DTPA

Tc-99m DTPA (diethylene-triamine-pentaacetate) is one of the technetium radiopharmaceuticals used in renal imaging and primarily used to measure the glomerular filtration rate (GFR). Characteristics photon energy: 140 KeV physical half-life: 6 hours biological half-life: 2.5 hours normal di...
Article

Tc-99m MAG3

Tc-99m MAG3 (mercaptoacetyltriglycine) is one of the technetium radiopharmaceuticals used in renal imaging. Characteristics photon energy: 140 KeV physical half life: 6 hours biological half life: 4 hours technetium oxidation state: +5 normal distribution: kidneys (100%) pharmacokinetics:...
Article

Tc-99m pertechnetate

Tc-99m pertechnetate (Na+ 99mTc O4-) is one of the technetium radiopharmaceuticals used in imaging of thyroid, colon, bladder and stomach. Technetium (99mTc) has eight oxidation states 6, from -1 to +7; specifically, the oxidation state of technetium in the pertechnetate anion (99mTcO4-) is +7....
Article

Tc-99m HMPAO labeled WBC

Tc-99m HMPAO (hexamethylpropyleneamine oxime) labeled WBC is one of the technetium radiopharmaceuticals used in WBC imaging. There are three potential radiochemical impurities in the 99mTc-HMPAO: a hydrophilic secondary complex, the free pertechnetate and the reduced 99mTc-hydrolyzate. 1The min...
Article

Tc-99m MAA

Tc-99m MAA (macroaggregated albumin) is one of the technetium radiopharmaceuticals used in lung perfusion imaging. Characteristics photon energy: 140 KeV physical half life: 6 hours biological half life: 2-3 hours normal distribution: lungs, liver, spleen, kidneys pharmacokinetics: >90% p...
Article

Tc-99m labeled RBC

Tc-99m labeled RBC is one of the technetium radiopharmaceuticals used in the assessment of GI bleeding. Characteristics photon energy: 140 KeV physical half-life: 6 hours biological half-life:  normal distribution: heart, vessels, spleen miscellaneous facts: threshold for detection is 0.0...
Article

Tc-99m sestamibi

Tc-99m sestamibi (sestamibi is a shortening of sesta-methoxyisobutylisonitrile) is one of the technetium radiopharmaceuticals. Characteristics photon energy: 140 KeV physical half-life: 6 hours lipophilic cation normal distribution: thyroid, parathyroid, heart (myocardium) excretion: hepat...
Article

Tc-99m DTPA (aerosol)

Tc-99m DTPA (diethylenetriamine-pentaacetic acid) (aerosol) is one of the technetium agents and is used in VQ imaging. Characteristics photon energy: 140 KeV physical half life: 6 hours biological half life: 1 hour normal distribution: lungs pharmacokinetics: aerosol deposited in bronhoal...
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Thallium-201 chloride

Thallium-201 chloride (TlCl) is a radiopharmaceutical used primarily in cardiac imaging. Thallium-201 is an analog of potassium; it is produced in cyclotron by bombarding thallium-203 with protons. Characteristics thallium is a monovalent cation photon energy: 68-80 keV (a smaller amount of γ...
Article

SeHCAT

SeHCAT™ (23-seleno-25-homo-tauro-cholic acid or tauroselcholic acid) is a radiopharmaceutical used in the investigation of bile salt malabsorption, which is a cause of chronic diarrhea.  Characteristics physical half-life: 118 days Uses, dosage and timings A capsule containing SeHCAT is inge...
Article

Iodine-131

Iodine-131​ (131I or I-131) is a radioisotope of iodine, which is used in the diagnosis and treatment of thyroid lesions. It is one of the oldest radiotracers used in nuclear medicine, in use for over 50 years. It is predominately used in thyroid ablation therapy, for patients post-thyroidectomy...

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