A generalized acceleration in bone maturation can result from a number of etiological factors. They include:
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endocrine disorders
idiopathic isosexual precocious puberty
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hypothalamic or parathalamic lesion with sexual precocity: e.g.
adrenogenital syndrome (adrenocortical tumor or hyperplasia)
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excessive androgen, estrogen or steroid administration or production: e.g.
virilizing adrenal or gonadal neoplasm or hyperplasia
pituitary gigantism: hyperpituitarism
hyperthyroidism (maternal or acquired): uncommon
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congenital disorders
McCune-Albright syndrome: polyostotic fibrous dysplasia with precocious puberty
lipodystrophy
acrodysostosis: uncommon
pseudohypoparathyroidism: uncommon
Weaver syndrome: uncommon
Marshall-Smith syndrome: uncommon
asphyxiating thoracic dysplasia: Jeune syndrome: uncommon
Beckwith-Wiedemann syndrome: uncommon
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others
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