From the case:
Temozolomide mechanism of action and resistance
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The action of temozolomide is influenced by a number of factors, including:
MGMT promoter methylation
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presence of mismatch repair
Case Discussion
Temozolomide is an alkylating agent used to treat various tumors, most commonly high-grade astrocytoma and glioblastoma. Its efficacy and likelihood of resulting pseudoprogression or hyper-mutated tumor recurrence are influenced by MGMT promoter methylation and the availability of mismatch repair enzymes.
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