Articles
Articles are a collaborative effort to provide a single canonical page on all topics relevant to the practice of radiology. As such, articles are written and continuously improved upon by countless contributing members. Our dedicated editors oversee each edit for accuracy and style. Find out more about articles.
22 results found
Article
Prostatic acid phosphatase
Prostatic acid phosphatase (PAP) also known as prostatic specific acid phosphatase (PSAP) is an enzyme generated by prostatic glandular tissue.
Usage
It can be used in immunohistochemistry to identify prostatic tissue including prostatic epithelium and prostatic ducts and is usually expressed ...
Article
Michaelis-Gutmann bodies
Michaeliis-Gutmann bodies are a histological feature characteristic of malakoplakia, typically seen in mid-stage disease 1,2.
They are 1–10 μm laminated or targetoid basophilic focal inclusions of iron and calcium salts seen on light microscopy. They are also periodic acid–Schiff, and diastase-...
Article
Estimated glomerular filtration rate
The estimated glomerular filtration rate (eGFR) is widely used as a surrogate marker of renal function and is mathematically derived from the patient's serum creatinine, using their age, sex and ethnicity. There is some controversy over whether ethnicity should be included in the calculations.
...
Article
Atresia
Atresia (plural: atresias) refers to a situation where there is absence, underdevelopment or abnormal closure, of a normal anatomical tubular structure or opening.
Contrast this with agenesis which refers to the complete absence of any anatomical structure including its primordial precursors.
...
Article
PSA velocity
The PSA velocity (PSAV) is a statistically-derived measure of how the prostate specific antigen (PSA) changes over time, and has been used as a marker of how prostate malignancy progresses or regresses.
Any cancer grows over time and relative changes of tumor markers, such as PSA, would seem t...
Article
Cyst
A cyst is an abnormal fluid-filled structure which is lined by epithelium; with one exception: lung cysts may contain gas or fluid. By contradistinction, a pseudocyst lacks an epithelial lining and instead has a vascular and fibrotic capsule.
Cysts are extremely common and found in most organs....
Article
Lamellated
The term lamellated (or laminated which means the same thing) is a radiopathological term used to describe the layered appearance of many calculi, including those of the renal tract, the salivary glands, and the biliary tree. The internal structure of these calculi has been likened to that of an...
Article
Angiotensin converting enzyme
Angiotensin converting enzyme (ACE) is a central component of the renin-angiotensin system (RAS) which assists in blood pressure control by regulating the volume of fluids in the body.
Normal individuals may have a small volume of the angiotensin converting enzyme circulating in their blood.
M...
Article
Schiller-Duval body (histology)
Schiller-Duval body is a perivascular structure that can be found in 50% of testicular yolk sac tumors also known as endodermal sinus tumors. If present it is considered pathognomonic.
Pathology
A central vessel is surrounded by tumor cells, and the cell-vessel complex is contained in a cysti...
Article
Atypical small acinar proliferation
Atypical small acinar proliferations (ASAP) are premalignant lesions of the prostate, which can be found in as many as 5% of prostate biopsies. They are suspicious glands without adequate histologic atypia to establish a definitive diagnosis of prostate cancer. Some studies showed that there is ...
Article
Hernia (general)
Hernias (or herniae) are a common pathological entity, in which an anatomical structure passes into an abnormal location via an opening.
The opening may be a normal physiological aperture (e.g. hiatus hernia: stomach passes through the diaphragmatic esophageal hiatus) or pathological. Iatrogeni...
Article
Lactate dehydrogenase
Lactate dehydrogenase (LDH or LD) is a key enzyme in most cells, catalyzing the reversible conversion of pyruvate to L-lactate. Its contemporaneous main clinical uses are limited primarily to the investigation of hemolysis, serous collections and as a tumor marker.
Physiology
L-lactate dehydro...
Article
Corpora amylacea
The corpora amylacea ("bodies of starch") are a histologic finding, encountered more frequently in the brain, prostate, lung, and uterus. The corpora amylacea are thought to be sulfated glycosaminoglycans 1. Some have described it as a localized amyloidosis 2.
In the prostate they appear to ar...
Article
Prostate specific antigen
Prostate specific antigen (PSA) is currently used as a tumor marker for prostate adenocarcinoma.
PSA is a 33 kilodalton glycoprotein produced in prostate epithelial cells. Its normal physiologic role is as a liquefying agent for seminal fluid; only a tiny amount leaks into the blood, therefore ...
Article
Metaplasia
Metaplasia is a general pathology term that refers to the process when one cell type is replaced by another. It usually occurs in the context of a changed cellular environment to which the new cell type is better adapted 1.
Examples include 2-5:
Barrett esophagus: normal squamous epithelium re...
Article
PSA density
The PSA density (PSAD) is calculated at diagnosis and is the serum prostate-specific antigen (PSA) level (ng/mL) divided by the prostate gland's volume (mL), resulting in a value in the units ng/mL2 1. Prostate volume is calculated from TRUS measurements, MRI measurements or, less commonly, rese...
Article
Fistula
A fistula (plural: fistulae or fistulas) is an abnormal connection between two epithelial surfaces such as between hollow organs, skin or vessels. Conventionally, the name of a specific fistula type is a combination of the two organs. For discussions of specific fistulae please refer to individu...
Article
Diverticulum
Diverticula are outpouchings of a hollow viscus and can be either true or false.
Occasionally a diverticulum is used in a more general sense to mean the outpouching of other anatomical structures, e.g. frontal intersinus septal cells are hypothesized to form as diverticula from the frontal sinu...
Article
Cystitis
Cystitis refers to inflammation of the urinary bladder. It may occur in isolation or be associated with inflammation of other parts of the urinary tract such as ureteritis or pyelonephritis.
Epidemiology
Cystitis is more common in females due to the short length of the urethra and its close pr...
Article
Von Brunn nests of the bladder
Von Brunn nests are non-neoplastic reactive urothelial lesions that occur in the bladder. They represent clusters of urothelial cells found in the superficial lamina propria resulting from the invagination of the superficial urothelium.
Histologically, those nests generally show uniform size a...
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