What is a basic differential diagnosis for a solitary lytic skull lesion?
The differential diagnosis for a solitary lytic skull lesion can be fairly broad. The margins of the lesion are a main distinguishing factor. A basic differential may include variant anatomy, metastasis, osteomyelitis, surgical defect, epidermoid cyst, langerhans cell histiocytosis, and hemangioma.
Head CT scout radiographs show a well marginated, osteolytic lesion in the right frontal/parietal calvarium with an overlying subcutaneous soft tissue defect and surrounding edema.