This case has classical abdominal and skeletal imaging features of an adult sickle cell disease patient:

• enlarged hyperdense liver, likely secondary hemochromatosis, due to serial blood transfusions
• atrophic calcified spleen (autosplenectomy)
• S/P cholecystectomy: higher rates of gallstones
• heterogeneous bone density of skeleton with H-shaped lumbar and thoracic vertebrae due to bone infarcts