Atypical meningioma - grade 2

Discussion:

The patient went on to have a resection. 

Histology

Sections show a meningeal base tumor which is attached to the dura.  The tumor consists of ahypercellular tumor which has sheet-like growth pattern with large nodules separated by fibrous bands.  Thetumour cells have oval nuclei with small nucleoli.  No significant nuclear pleomorphism is seen.  The cellshave a small amount of eosinophilic cytoplasm.  The tumor has increased cellularity with areas of sheet-likegrowth pattern.  Areas with small cell-like change are present.  Mitotic figures are not conspicuous up to 2 mitoses per 10 high power field are seen.  Immunohistochemistry shows tumor stains strongly positive with SSTR2 and negative for STAT6. 

 Bone flap:  Decalcified sections show bone with focal fibroblastic tissue. No tumor identified

Final diagnosis:

Atypical meningioma WHO grade 2

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