Fetal hydantoin syndrome
Last revised by Rohit Sharma on 22 Feb 2024
Citation, DOI, disclosures and article data
Citation:
Radswiki T, Sharma R, Smith H, et al. Fetal hydantoin syndrome. Reference article, Radiopaedia.org (Accessed on 07 Jul 2024) https://doi.org/10.53347/rID-13974
rID:
13974
Article created:
5 Jun 2011,
The Radswiki ◉
Disclosures:
At the time the article was created The Radswiki had no recorded disclosures.
View The Radswiki's current disclosures
Last revised:
22 Feb 2024,
Rohit Sharma ◉
Disclosures:
At the time the article was last revised Rohit Sharma had no financial relationships to ineligible companies to disclose.
View Rohit Sharma's current disclosures
Revisions:
4 times, by
3 contributors -
see full revision history and disclosures
Systems:
Tags:
Synonyms:
- Hydantoin embryopathy
- Phenytoin embryopathy
- Dilantin embryopathy
- Fetal phenytoin syndrome
The fetal hydantoin syndrome refers to a spectrum of features that can develop in a small proportion (~ 10% 5) of women taking the antiseizure medication phenytoin (DilantinTM) during pregnancy.
Clinical presentation
-
CNS anomalies
increased risk of intracranial bleeding
References
- 1. Buehler BA, Bick D, Delimont D. Prenatal prediction of risk of the fetal hydantoin syndrome. N. Engl. J. Med. 1993;329 (22): 1660-1. doi:10.1056/NEJM199311253292219 - Pubmed citation
- 2. Buehler BA, Delimont D, Van waes M et-al. Prenatal prediction of risk of the fetal hydantoin syndrome. N. Engl. J. Med. 1990;322 (22): 1567-72. doi:10.1056/NEJM199005313222204 - Pubmed citation
- 3. Silver L. Hand abnormalities in the fetal hydantoin syndrome. J Hand Surg Am. 1981;6 (3): 262-5. - Pubmed citation
- 4. Barr M, Poznanski AK, Schmickel RD. Digital hypoplasia and anticonvulsants during gestation: a teratogenic syndrome? J. Pediatr. 1974;84 (2): 254-6. - Pubmed citation
- 5. Buehler BA, Rao V, Finnell RH. Biochemical and molecular teratology of fetal hydantoin syndrome. Neurol Clin. 1994;12 (4): 741-8. - Pubmed citation
- 6. Sabry MA, Farag TI. Hand anomalies in fetal-hydantoin syndrome: from nail/phalangeal hypoplasia to unilateral acheiria. Am. J. Med. Genet. 1996;62 (4): 410-2. doi:10.1002/ajmg.1320620403 - Pubmed citation