14-3-3 protein
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14-3-3 protein is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic Creutzfeldt-Jakob disease (sCJD).
In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and the specificity is 80% 1. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.
Results need to be correlated with patient's history as CSF 14-3-3 can be false positive in acute stroke, encephalitis, and other dementias 1.
-<p><strong>14-3-3 protein </strong>is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic Creutzfeldt-Jakob disease (sCJD). </p><p>In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and the specificity is 80% <sup>1</sup>. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.</p><p>Results need to be correlated with patient's history as CSF 14-3-3 can be false positive in acute <a title="Ischaemic stroke" href="/articles/ischaemic-stroke">stroke</a>, <a title="encephalitis" href="/articles/encephalitis">encephalitis</a>, and other dementias <sup>1</sup>.</p><p> </p>- +<p><strong>14-3-3 protein </strong>is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic Creutzfeldt-Jakob disease (sCJD). </p><p>In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and the specificity is 80% <sup>1</sup>. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.</p><p>Results need to be correlated with patient's history as CSF 14-3-3 can be false positive in acute <a href="/articles/ischaemic-stroke">stroke</a>, <a href="/articles/encephalitis">encephalitis</a>, and other dementias <sup>1</sup>.</p>
References changed:
- 1. Muayqil T, Gronseth G, Camicioli R. Evidence-Based Guideline: Diagnostic Accuracy of CSF 14-3-3 Protein in Sporadic Creutzfeldt-Jakob Disease. Neurology. 2012;79(14):1499-506. <a href="https://doi.org/10.1212/wnl.0b013e31826d5fc3">doi:10.1212/wnl.0b013e31826d5fc3</a>
- 2. Vitali P, Maccagnano E, Caverzasi E et al. Diffusion-Weighted MRI Hyperintensity Patterns Differentiate CJD from Other Rapid Dementias. Neurology. 2011;76(20):1711-9. <a href="https://doi.org/10.1212/wnl.0b013e31821a4439">doi:10.1212/wnl.0b013e31821a4439</a>
- 3. Samson K. AAN Guideline. Neurology Today. 2012;12(19):6. <a href="https://doi.org/10.1097/01.nt.0000421885.44638.a9">doi:10.1097/01.nt.0000421885.44638.a9</a>
Systems changed:
- Central Nervous System