14-3-3 protein
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- updated 10 Jun 2024:
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14-3-3 proteins arefound in the cerebrospinal fluid (CSF) and and are currently used to help identify patients with sporadic Creutzfeldt-Jakob disease (sCJD).
Seven distinct 14-3-3 proteins have been found in humans.
In diagnosing sCJD, the the sensitivity of 14-3-3 protein is 92%, and its specificity is 80% 1. A negative 14-3-3 assay may help reduce the suspicion of sCJD.
Results need to be correlated with the patient's history as CSF 14-3-3 can be falsely positive in acute stroke, encephalitis, and other dementias 1.
History and etymology
The unusual name of the protein family derived from the time of the first protein's discovery when it was found to distribute in the 14th fraction when eluted with DEAE chromatography, and then within fraction 3.3 after additional analysis with gel electrophoresis 4.
-<p><strong>14-3-3 proteins </strong>are<strong> </strong>found in the <a href="/articles/cerebrospinal-fluid-1">cerebrospinal fluid (CSF)</a> and are currently used to help identify patients with <a href="/articles/creutzfeldt-jakob-disease">sporadic Creutzfeldt-Jakob disease (sCJD)</a>. </p><p>Seven distinct 14-3-3 proteins have been found in humans.</p><p>In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92%, and its specificity is 80% <sup>1</sup>. A negative 14-3-3 assay may help reduce the suspicion of sCJD.</p><p>Results need to be correlated with the patient's history as CSF 14-3-3 can be falsely positive in acute <a href="/articles/ischaemic-stroke">stroke</a>, <a href="/articles/encephalitis">encephalitis</a>, and other <a href="/articles/causes-of-dementia-mnemonic">dementias</a> <sup>1</sup>.</p><h4>History and etymology</h4><p>The unusual name of the protein family derived from the time of the first protein's discovery when it was found to distribute in the 14th fraction when eluted with DEAE chromatography, and then within fraction 3.3 after additional analysis with gel electrophoresis <sup>4</sup>.</p>- +<p><strong>14-3-3 proteins </strong>are<strong> </strong>found in the <a href="/articles/cerebrospinal-fluid-1">cerebrospinal fluid (CSF)</a> and are used to help identify patients with <a href="/articles/creutzfeldt-jakob-disease">sporadic Creutzfeldt-Jakob disease (sCJD)</a>. </p><p>Seven distinct 14-3-3 proteins have been found in humans.</p><p>In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92%, and its specificity is 80% <sup>1</sup>. A negative 14-3-3 assay may help reduce the suspicion of sCJD.</p><p>Results need to be correlated with the patient's history as CSF 14-3-3 can be falsely positive in acute <a href="/articles/ischaemic-stroke">stroke</a>, <a href="/articles/encephalitis">encephalitis</a>, and other <a href="/articles/causes-of-dementia-mnemonic">dementias</a> <sup>1</sup>.</p><h4>History and etymology</h4><p>The unusual name of the protein family derived from the time of the first protein's discovery when it was found to distribute in the 14th fraction when eluted with DEAE chromatography, and then within fraction 3.3 after additional analysis with gel electrophoresis <sup>4</sup>.</p>
References changed:
- 1. Muayqil T, Gronseth G, Camicioli R. Evidence-Based Guideline: Diagnostic Accuracy of CSF 14-3-3 Protein in Sporadic Creutzfeldt-Jakob Disease. Neurology. 2012;79(14):1499-506. <a href="https://doi.org/10.1212/wnl.0b013e31826d5fc3">doi:10.1212/wnl.0b013e31826d5fc3</a>
- 2. Vitali P, Maccagnano E, Caverzasi E et al. Diffusion-Weighted MRI Hyperintensity Patterns Differentiate CJD from Other Rapid Dementias. Neurology. 2011;76(20):1711-9. <a href="https://doi.org/10.1212/wnl.0b013e31821a4439">doi:10.1212/wnl.0b013e31821a4439</a>
- 4. Ralph A. Bradshaw, Edward A. Dennis. Handbook of Cell Signaling. (2009) ISBN: 9780080920917 - <a href="http://books.google.com/books?vid=ISBN9780080920917">Google Books</a>
- 1. Muayqil T, Gronseth G, Camicioli R. Evidence-based guideline: Diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2012;79(14):1499-1506. <a href="https://doi.org/10.1212/wnl.0b013e31826d5fc3">doi:10.1212/wnl.0b013e31826d5fc3</a>
- 2. Vitali P, Maccagnano E, Caverzasi E et al. Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias. Neurology. 2011;76(20):1711-1719. <a href="https://doi.org/10.1212/wnl.0b013e31821a4439">doi:10.1212/wnl.0b013e31821a4439</a>
- 4. Ralph A. Bradshaw, Edward A. Dennis. Handbook of Cell Signaling. (2009-11-03) ISBN: 9780080920917